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KMID : 0371320000590010039
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Journal of the Korean Surgical Society
2000 Volume.59 No. 1 p.39 ~ p.45
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A Study of the Expression of p53 and the Product of bcl-2 in Early and Advanced Gastric Cancers
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Shin Hyuk-Jai
Lee Doo-Sun
Kim Jung-Teak
Jung Min
Ryu Jin-Woo
Park Jong-Kweon
Kang Bong-Jin
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Abstract
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Purpose :To evaluate of the role in carcinogenesis of p53 over-expression and bcl-2 inhibition in early gastric and advanced gastric cancers, we investigated the immunohistochemical tissue status of 31 primary early gastric-cancer patients and 31 primary advanced gastric-cancer patients.
Methods :DO7, the monoclonal antiserum to the P53 protein, and clone 124, the monoclonal antibody to the bcl-2 protein, were used for the immunohistochemical analysis of the 31 surgically resected primary early gastric cancer specimens and the 31 surgically resected advanced gastric-cancer specimens. The expressions were scored and divided into negative, positive, low expression, and overexpression.
Results :The clinicopathologic parameter; tumor depth of invasion, histologic type, and differentiation, were not related with the expression status of p53 or bcl-2. Of the 31 primary early gastric-cancer patients, 14 exhibited p53 overexpression and 16 showed negative the bcl-2 expression; 5 cases had both p53 overexpression and negative bcl-2 expression. Of the 31 advanced gastric cancer patients, 19 showed the p53 overexpression, and negative bcl-2 expression, 15 exhibited both p53 overexpression and negative bcl-2 expression.
Conclusion :These results suggest that cell cycle alteration and apoptosis control by p53 and bcl-2 may play roles in the carcinogenesis of gastric cancer. However, there are many other mediators that may facilitate carcinogenesis. This study proved that bcl-2 is a valuable prognostic factor.
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KEYWORD
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Gastric cancer, Apoptosis, Immunohistochemical analysis, p53, bcl-2,
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